Table 2.
OR with 95% CI of developing MS among subjects categorized by EBNA1 status and smoking.
| EBNA-1 IgG | Smoking | ca/coa | OR (95% CI)b | OR (95% CI)c | AP (95% CI) |
|---|---|---|---|---|---|
| Low | Never | 689/1656 | 1.0 (reference) | 1.0 (reference) | |
| Low | Ever | 808/1389 | 1.4 (1.3 to 1.6) | 1.5 (1.3 to 1.7) | |
| High | Never | 2085/1642 | 3.1 (2.7 to 3.4) | 2.7 (2.4 to 3.0) | |
| High | Ever | 2758/1532 | 4.4 (3.9 to 4.9) | 3.8 (3.4 to 4.3) | 0.2 (0.1 to 0.3) |
| Low | Never | 689/1656 | 1.0 (reference) | 1.0 (reference) | |
| Low | Current | 505/814 | 1.5 (1.3 to 1.7) | 1.6 (1.4 to 1.8) | |
| High | Never | 2085/1642 | 3.1 (2.7 to 3.4) | 2.7 (2.4 to 3.0) | |
| High | Current | 1820/887 | 4.9 (4.4 to 5.5) | 4.4 (3.9 to 5.0) | 0.3 (0.2 to 0.4) |
| Low | Never | 689/1656 | 1.0 (reference) | 1.0 (reference) | |
| Low | Past | 303/575 | 1.3 (1.1 to 1.5) | 1.4 (1.1 to 1.6) | |
| High | Never | 2085/1642 | 3.1 (2.7 to 3.4) | 2.7 (2.4 to 3.0) | |
| High | Past | 938/645 | 3.6 (3.1 to 4.1) | 3.1 (2.7 to 3.6) | 0.01 (− 0.1–0.1) |
AP with 95% CI between high EBNA1 IgG and smoking.
aNumber of exposed cases and controls
bAdjusted for age, sex, residential area, study, and ancestry
cAdjusted for age, sex, residential area, study, ancestry, infectious mononucleosis, adolescent body mass index, DRB1*1501, DRB1*0301, DRB1*1303, DRB1*0801, A*0201, B*4402, B*3801, B*5501, DQA1*0101, DQB1*0302, DQB1*0301, homozygote correction for DRB1*1501, DRB1*0301, and A*0201.