Table 1.
FBXO45 targets substrates for degradation in human diseases.
| Substrates | Cell lines | Functions | Reference |
|---|---|---|---|
| ERα | HeLa, MCF-7 | Involves in tissue-selective oestrogen complex-mediated endometriosis therapy | 10 |
| Munc13-1 | 293T, hippocampal neuron cells, COS. | Controls synaptic activity, neuropathic allodynia | 12,13 |
| NMNAT2 | 293T | Regulates axon degeneration | 17,18 |
| p73 | BT-20, 293T, HeLa | Reduction of cell death | 24 |
| Par-4 | HeLa, 293T | Reduction of cell apoptosis, promotes cell survival | 25 |
| FBXW7 | U2OS, HeLa | Governs cell fate decision, chemotherapy resistance | 27 |
| ZEB1/2, Snail1/2, Twist1 | 293T, HeLa, U2OS, MCF-7, MDA-MB-231, PANC-1 | Regulates EMT | 29,30 |