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. 2020 Jul 3;10:10986. doi: 10.1038/s41598-020-67755-3

Figure 2.

Figure 2

Loss of islet Bax and/or global Bak deletion does not affect body weight or in vivo glucose tolerance. Intraperitoneal glucose tolerance tests (IPGTT; 2 g/kg) and body weight analyses were performed in WT, Bax SKO, Bak SKO, and Bax-Bak DKO mice at 12–16 weeks of age. IPGTT blood glucose kinetics, area under the curve (AUC) of IPGTT profiles, and body weights, were not different between genotypes in male (a–c) and female (d–f) animals (n = 15–30 animals of each genotype in each sex for body weight data; n = 7–12 animals of each genotype in each sex for IPGTT data). Data represent mean ± SEM. a.u. arbitrary units. Statistical comparisons were done using 1-way ANOVA with Bonferroni post-hoc tests.