Table 1 .
Descriptive characteristics of both cohorts.
| healthy controls | IBS patients | p-value | |
|---|---|---|---|
| Sendai cohort | |||
| n | 29 | 30 | |
| age | 22 [20–23] | 21 [20–23] | 0.56 |
| sex (m/f) | 15/14 (52/48%) | 13/17 (43/57%) | 0.52° |
| IBS-SSS GI symptoms | 41 [12–80] | 179.5 [139–203] | <0.0001 |
| STAI trait anxiety | 36 [33–40.5] | 38.5 [31.5–45] | 0.38 |
| SDS depressive symptoms | 35.5 [32.5–38] | 35.5 [31–43.5] | 0.73 |
| VSI GI-specific anxiety | 1 [0–5] | 24.5 [13.5–33] | <0.0001 |
| Gothenburg cohort | |||
| n | 29 | 62 | |
| age | 29 [26–33] | 31 [26–39] | 0.29 |
| sex (m/f) | 10/19 (34/66%) | 17/45 (27/73%) | 0.49° |
| IBS-SSS GI symptoms | 12 [4–29] | 295 [197–358] | <0.0001 |
| IBS-SSS extracolonic symptoms | 33.5 [15.5–52.5] | 155.25 [100.5–223.0] | <0.0001 |
| HADS anxiety symptoms | 4 [1–5] | 9 [6–12] | <0.0001 |
| HADS depressive symptoms | 1 [0–2] | 5 [3–7] | <0.0001 |
| VSI GI-specific anxiety | 1 [0–2] | 39 [24–51] | <0.0001 |
Values are median [25th percentile-75th percentile] or n (%); p-values are from Kruskal-Wallis non-parametric one-way ANOVAs, except for ° from Pearson χ² test; italic indicates significant group differences.
IBS, irritable bowel syndrome; IBS-SSS, IBS severity scoring system; STAI, Spielberger State-Trait Anxiety Inventory; SDS, Zung Self-rating Depression Scale; HADS, hospital anxiety & depression scale; VSI, visceral sensitivity index.