Table 5.
Significant differences in probability to be a hub between IBS patients and healthy controls.
| node | % hub in healthy controls | % hub in IBS patients | p-value (uncorrected) |
|---|---|---|---|
| Sendai cohort | |||
| left anterior insula | 28 | 10 | 0.038 |
| left middle insula | 3 | 20 | 0.020 |
| left SI | 21 | 40 | 0.049 |
| left SII | 7 | 57 | <0.0001* |
| right PCC | 45 | 20 | 0.018 |
| right putamen | 21 | 3 | 0.017 |
| Gothenburg cohort | |||
| left angular gyrus | 21 | 48 | 0.002 |
| left middle insula | 28 | 11 | 0.038 |
| left mPFC | 21 | 39 | 0.032 |
| left pACC | 41 | 19 | 0.017 |
| right hippocampus | 17 | 3 | 0.029 |
| right LTC | 17 | 32 | 0.050 |
| right sACC | 17 | 2 | 0.015 |
*Significant after FDR correction for multiple testing.
IBS, irritable bowel syndrome; LTC, lateral temporal cortex; PCC, posterior cingulate cortex; SII, secondary somatosensory cortex; mPFC, medial prefrontal cortex; pACC, pregenual anterior cingulate cortex; sACC, subgenual anterior cingulate cortex.