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. Author manuscript; available in PMC: 2021 Jun 8.
Published in final edited form as: Dev Cell. 2020 May 21;53(5):545–560.e7. doi: 10.1016/j.devcel.2020.04.018

Figure 7. Working model of tankyrase-mediated ligand-independent β-catenin activation resulting in MYC production to support embryo development.

Figure 7.

See Discussion for full model description. Sites of action of inhibitors are indicated. TNKS, tankyrase 1; APC, adenomatosis polyposis coli; β-cat, β-catenin; CKI, casein kinase I; GSK3, glycogen synthase kinase 3; TCF/LEF, T-cell factor/lymphoid enhancer-binding factor proteins.