Table 5.
Anti-HIV-1 activity (EC50), toxicity (TC50), and SI of resveratrol and derivatives from Ref. [84].
| Compound | EC50 (μM) | TC50a (μM) | SIb |
|---|---|---|---|
| resveratrol | >75 | >300 | ND |
| piceatannol | 21.4 | >400 | >18.7 |
| 19 | >75 | ND | ND |
| 20 | >75 | ND | ND |
| 21 | >75 | ND | ND |
| 22 | >75 | ND | ND |
| 23a | 8.8 | 179 | 20.3 |
| 23b | >100 | ND | ND |
| 23c | >75 | ND | ND |
| 23d | >75 | ND | ND |
| 23e | >75 | ND | ND |
| 23f | >75 | ND | ND |
| 24a | 35.0 | 84.8 | 2.4 |
| 24b | 34.4 | 131 | 3.8 |
| 24c | 65.1 | 108 | 1.5 |
| 24d | 45.1 | 118 | 2.6 |
a
Concentration of compound that induces toxicity in 50% of the host cells.
b
Selectivity index: TC50/EC50.