Table 6.

Antiretroviral activity of M8 against laboratory strains of HIV-1 in different cells from Refs. [87].

Variant	Cell line	Assay	EC50 (μM)a	CC50 (μM)	SI
NL 4–3 (X4)	MT-4	MTT	0.74 $\pm$ 0.081	11.9 $\pm$ 1.1	16
NL 4–3 (X4)	TZM-bl	Luc	0.29 $\pm$ 0.031	20.1 $\pm$ 1.9	69
Bal (R5)	TZM-bl	Luc	1.69 $\pm$ 0.17	20.1 $\pm$ 1.9	12

^aEC₅₀: 50% effective concentration, determined in MT-4 cells against NL4-3 HIV-1 by MTT or luciferase activity (Luc) in TZM-bl cells.