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. 2020 Jul 4;202:112541. doi: 10.1016/j.ejmech.2020.112541

Table 7.

Antiviral activity of the most active stilbenoids.

Compound Virus Target Activity (μM) and cell lines Ref.
Hopeaphenol Influenza A (A/NWS/33, H1N1) NI IC50 = 6.4 μM on MDCK Ito [33]
Gnetin D - A/PR/8/34 (H1N1)
- A/Guangdong/243/72 (H3N2)
- B/Jiangsu/10/2003		 NI IC50 = 0.67 μg/mL (6.4 μM) (H3N2) on MDCK Liu [34]
(+)-Vitisin A Influenza A (A/PR/8/34, H1N1)- ↓ RANTES EC50 = 0.27 μM on Human alveolar epithelial A549 Huang [38]
2b Influenza A (A/PR/8/34, H1N1) Neuraminidase EC50 = 7.28 μg/mL (28 μM) on MDCK Li [39]
Resveratrol MERS-CoV (HCoV-EMC/2012) Interference with NF-κB pathway Vero E6 (CRL-1586) Lin [45]
5 SARS-CoV NI Vero E6 Li [40]
6 NI
Z-3, 4′, 5-trimethoxy stilbene (Z-TMS) - HCV-1b replicon (FCA4), JFH1
- HCV-2a (HCVcc)		 ↓ HCV NS5B Hepatoma Huh7-derived (Huh7.5, GS5 and FCA4)
FCA4-HCV+DCLK1+ 		Ngu yen [55]
Vitisin B - HCV-2a (Rluc-J6/JFH1, J6/JFH1),
- HCV-1b Con1 sequence (Bart79I)
- HCVcc expressing an HCV NS5A-GFP fusion protein		 ↓ HCV NS3 EC50 = 0.003 μM (2a genotype)
EC50 = 0.001 μM (1b genotype) on Huh7.5		 Lee [57]
(+)-ϵ-Viniferin ↓ HCV NS3 EC50 = 2.9 μM (2a genotype)
EC50 = 7.0 μM (1b genotype) on Huh7.5		 Lee [58]
(±)-ϵ-VF ↓ HCV NS3 EC50 = 9.3 μM (2a genotype) on Human hepatoma Huh7.5
EC50 = 1.7 μM (1b genotype)		 Lee [58]
(±)-ϵ-VF-5Ac NI EC50 = 4.7 μM (2a genotype)
EC50 = 10.4 (1b genotype) ∗∗ on Huh7.5
PNR-4-44 DENV-2-induced CPE ↓ RNA viral synthesis EC50 = 8.12 nM (0.00812 μM) Han [66]
PNR-5-02 ↓ RNA viral synthesis and host cell factors interference EC50 = 7.22 nM (0.00722 μM)
Pterostilbene HIV-1 ↓ integrase, prevents CD4 T cells infection Activated T and transformed T Jurkat (clone E6), IL-4 treated CD4 T and Resting CD4 Chan [72]
Leachianol G HIV-1 ↓ integrase 293T Pflie ger [73]
Resveratrol HIV-1 Prevents CD4 T cells infection, synergism with RNR inhibitors EC50 = 4.37 μg/mL (19 μM) on C8166 Lin [74]
14 NI EC50 = 84.77 μg/mL (172 μM) on C8166
Dibalanocarpol HIV-1 NI EC50 = 46 μM on CEM-SS Dai [75]
Balanocarpol NI EC50 = 20 μM on CEM-SS
DIDS HIV-1 strain RF
HIV-1 strain GB8		 Binding to coreceptor CD4 IC50 = 20 μM on JM Cardin [76]
H2DIDS IC50 = 40 μM on JM
NSC34931 (stilbenavir) HIV-1 ↓ Integrase IC50 = 0.32 μM
EC50 = 3.07 μM on MT4-LTR-eGFP		 Aknin [77]
NSC34933 HIV-1 ↓ Integrase IC50 = 1.1 μM
EC50 = 0.60 μM on MT4-LTR-eGFP
CGA137053 HIV-1 Binding to Tat protein EC90 = 0.5–5 μM on Human leucocytes (PBL) and macrophages Hamy [82]
23a HIV-1 NI EC50 = 8.8 μM) on 293T Clouser [70]
M8 HIV-1 NL 4–3 or BaL variants ↓ viral attachment EC50 = 0.29–1.69 μM on MT-4 and TZM-bl cells Han [87]
28 HNV ↓ RNA viral replication EC50 = 2.43 μM on HG23 cells Harmalkar [91]
Resveratrol HRV1B
CVB3
EV71		 NI IC50 = 29.7 μM (HRV1B) on Hela Oh [94]
cis-resveratrol NI IC50 = 12.2 μM (CVB3)
IC50 = 37.6 μM (EV71) on Vero
Vadelianin EV 7, 13 and 19 serotypes NI IC50 = 0.0036 nM (0.0036 • 10−3 μM) on Human rhabdomyosarcoma (RD) Segun [95]
Kuwanon X HSV-1 (15577 and clinical strains)
HSV-2 (333 strains)		 ↓ viral adsorption, penetration, proteins, DNA biosynthesis, NF-κB pathway IC50 = 2.2 μg/mL (3.77 μM) (15577 strain)
IC50 = 1.5 μg/mL (2.57 μM) (clinical strain)
IC50 = 2.5 μg/mL (4.29 μM) (333 strain) on Vero and Hela		 Ma [23]
(−)-hopeaphenol HSV-1
HSV-2		 NI IC50 = 2.8 μM (HSV-1)
IC50 = 6.4 μM (HSV-2) on MDCK		 Ito [33]
Shoreaketone IC50 = 2.8 μM (HSV-1)
IC50 = 6.8 μM (HSV-2) on MDCK
Vaticaffinol HSV-1 (strain 17)
HSV-2 strain G (VR-734)		 Promotes ROS production IC50 = 3.2 μM (HSV-2) on HeLa, Vero, and H1299 Chen [103]
Oxyresveratrol HSV-1 (7401H and KOS)
HSV-2 (Baylor 186) TK-deficient HSV-1 strain (B2006 strain) and PAA-resistant strain		 Inhibition of late viral proteins IC50 = 19.8 μg/mL (81.0 μM) (7401H)
IC50 = 24 μg/mL (98.2 μM) (KOS)
IC50 = 18.7 μg/mL (76.6 μM) (Baylor 186) on Vero (ATCC CCL81)		 Chuanasa [105]

NI= Not Identified.