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. 2020 Jun 30;13:6295–6302. doi: 10.2147/OTT.S253082

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© 2020 Liu et al.

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SLC7A11-AS1 directly bound to miR-4775 and regulated its expression negatively. (A) The WT-SLC7A11-AS1 and MUT-SLC7A11-AS1 sequences containing the miR-4775 binding site were synthesized. (B) H1299 and A549 cells of miR-4775 group were with much higher relative miR-4775 expression than those of NC group. (C and D) Relative to H1299 and A549 cells in NC group, the relative luciferase activity of WT-SLC7A11-AS1 reporter in miR-4775 group was prominently inhibited, but that of MUT-SLC7A11-AS1 reporter in miR-4775 group was not obviously changed. (E) Compared with NC group, H1299 and A549 cells of WT-bio-miR-4775 group had significantly higher SLC7A11-AS1 enrichment, whereas those of MUT-bio-miR-4775 group had not obviously changed in SLC7A11-AS1 enrichment. (F) For H1299 and A549 cells of si-SLC7A11-AS1-1 group and si-SLC7A11-AS1-2 group, markedly higher miR-4775 relative expression was observed when relative to si-NC group. *P < 0.05.