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. 2020 Jun 30;13:6295–6302. doi: 10.2147/OTT.S253082

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© 2020 Liu et al.

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miR-4775 could target TRAIP and regulate its expression negatively. (A) The WT-TRAIP and MUT-TRAIP sequences containing the binding site for miR-4775 was synthesized. (B and C) Relative to H1299 and A549 cells of NC group, the relative luciferase activity of WT-TRAIP reporter was markedly weakened by miR-4775 mimics, but that of MUT-TRAIP reporter was not obviously affected by miR-4775 mimics. (D and E) H1299 and A549 cells of miR-4775 group showed remarkably lower relative TRAIP expression than that of NC group. (F) In tumor tissues of lung cancer patients, TRAIP expression was negatively correlated with the expression of miR-4775. *P < 0.05.