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. 2020 Jun 30;12:5181–5200. doi: 10.2147/CMAR.S250661

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© 2020 Xu et al.

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The regulatory effects of LACTB on autophagy and EMT are partially due to the PI3K/AKT signaling pathway. (A–C) Western blotting showed that PIK3R3 and PI3K expression was clearly decreased in the two LACTB-overexpressing cell lines compared with the control cell lines, whereas the LACTB-knockdown LOVO cells showed high PIK3R3 and PI3K expression. Simultaneously, the levels of p-AKT and mTOR were decreased after LACTB overexpression, and the LACTB-silenced LOVO cells showed increased levels of these proteins. In addition, 4E-BP1 exhibited adverse outcomes (*P<0.05), as determined by Student’s t-test.