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Schematic diagram of the mechanism through which LACTB inhibits EMT and promotes autophagy in CRC via the PI3K/AKT/mTOR signaling pathway. By overexpressing and silencing LACTB and PIK3R3, we demonstrated that LACTB might negatively regulate PIK3R3 to inhibit cancer development. In addition, LACTB can inhibit EMT by promoting autophagy and decreasing the level of Twist1.
