. Author manuscript; available in PMC: 2021 Jan 1.

Published in final edited form as: Cancer Prev Res (Phila). 2020 Mar 13;13(7):601–610. doi: 10.1158/1940-6207.CAPR-19-0457

Table 2.

HRs (95% CI) for quintiles of CML-AGE intake and breast cancer risk in the PLCO

	Quintiles of CML-AGE intake					P-trend

	Q1	Q2	Q3	Q4	Q5
Cases, n	285	324	330	326	327
CML-AGE, KU/1000 kcal	867–4056	4057–5136	5137–6208	6209–7731	7732–43387
HR (95%CI)^a	Ref	1.15 (0.98–1.34)	1.17 (1.00–1.37)	1.18 (1.00–1.38)	1.20 (1.02–1.41)	0.05
HR (95%CI)^b	Ref	1.14 (0.97–1.34)	1.16 (0.99–1.37)	1.19 (1.01–1.40)	1.23 (1.04–1.46)	0.02
HR (95%CI)^c	Ref	1.16 (0.98–1.37)	1.19 (1.00–1.42)	1.24 (1.02–1.50)	1.30 (1.04–1.62)	0.04

Abbreviations: AGE, Advanced glycation end-products; CML, N^Ɛ-carboxymethyl-lysine

Adjusted for age and energy intake

Adjusted for covariates age, energy intake, alcohol, BMI, vigorous activity, race, marital status, education, study center, smoking status, family history, age at menarche, age at menopause, age at first birth, no. of live birth, PMH use, OC use, oophorectomy, hysterectomy

Adjusted for all covariates in ^b and dietary intake of total fat and red meat