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(A) Structure of BMS-P5, a selective PAD4 inhibitor. (B,C) Neutrophils isolated from the BM of 3 individual mice were cultured for 6h with or without 1 μM BMS-P5. Neutrophil viability (B) and apoptosis (C) were determined. (D) Indicated mouse myeloma cells were treated with BMS-P5 for 24h followed by detection of apoptosis. Mean and SD values are shown.
