Figure 3.

A) Stereoview of the Polder omit maps of the HDAC6‐3a complex (monomer A, contoured at 3.5 σ, PDB 6VNR). Atoms are color‐coded as follows: C=light blue (HDAC6), dark gray (symmetry mate), or wheat (inhibitor), N=blue, O=red, Zn²⁺=gray sphere, and solvent=small red spheres. Metal coordination and hydrogen bond interactions are indicated by solid and dashed black lines, respectively. B) Stereoview of a superposition of the complexes of 3a with HDAC6 and HDAC10. Atoms are color‐coded as follows: C=light blue (HDAC6) or white (HDAC10), dark gray (symmetry mate of HDAC6), wheat (3a bound to HDAC6), orange (3a bound to HDAC10), N=blue, O=red, and Zn²⁺=gray sphere.