TABLE 2.
Compound, µM | Effect of dyad (or family) on mixed model2 | Family (dyad) effect variance | Plate-adjusted compound variance | Effect size of family on compound concentrations,3 % |
---|---|---|---|---|
TMAO4 |
P < 0.0001
|
0.25 | 0.67 | 37 |
l-Carnitine |
P < 0.0001
|
63.92 | 249.62 | 26 |
DMG4 |
P < 0.0001
|
0.05 | 0.12 | 36 |
Betaine |
P < 0.0001
|
29.86 | 136.01 | 22 |
Choline |
P < 0.0001
|
0.90 | 7.07 | 13 |
1DMG, dimethylglycine; TMAO, trimethylamine N-oxide.
Log likelihoods were derived from mixed models including generation as a fixed effect, with or without family as a random effect.
Calculated as the family (dyad) effect variance divided by the plate-adjusted compound variance × 100.
Log-transformed variable.