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. Author manuscript; available in PMC: 2021 Jul 1.

Published in final edited form as: J Thromb Thrombolysis. 2020 Jul;50(1):98–111. doi: 10.1007/s11239-020-02112-9

Fig. 2 — Significantly increased tissue factor (TF) expression and decreased thrombomodulin (TM) expression in the ligated inferior vena cava (IVC) of Akt2^−/− mice. Wild-type (WT) mice and Akt2^−/− mice underwent a sham operation or IVC ligation. The thrombus-containing IVC was harvested from each mouse 2 weeks after ligation. Representative images of immunofluorescence staining and quantification showing increased TF expression (a) and decreased TM expression (b) in the ligated IVC of Akt2^−/− mice. For the quantification of staining, the mean positive-staining area was normalized with the evaluated area. All values represent the mean (n = 6 per group). P-values were obtained by performing multiple comparisons in one-way ANOVA analysis followed by the Tukey multiple comparisons test. c Representative images of immunofluorescence staining showing decreased endothelial protein C receptor (EPCR) expression in the ligated IVC of Akt2^−/− mice

Fig. 2 — Significantly increased tissue factor (TF) expression and decreased thrombomodulin (TM) expression in the ligated inferior vena cava (IVC) of Akt2^−/− mice. Wild-type (WT) mice and Akt2^−/− mice underwent a sham operation or IVC ligation. The thrombus-containing IVC was harvested from each mouse 2 weeks after ligation. Representative images of immunofluorescence staining and quantification showing increased TF expression (a) and decreased TM expression (b) in the ligated IVC of Akt2^−/− mice. For the quantification of staining, the mean positive-staining area was normalized with the evaluated area. All values represent the mean (n = 6 per group). P-values were obtained by performing multiple comparisons in one-way ANOVA analysis followed by the Tukey multiple comparisons test. c Representative images of immunofluorescence staining showing decreased endothelial protein C receptor (EPCR) expression in the ligated IVC of Akt2^−/− mice