. Author manuscript; available in PMC: 2021 May 1.

Published in final edited form as: Lancet Respir Med. 2020 May;8(5):482–492. doi: 10.1016/S2213-2600(20)30011-4

Table 3. Effect sizes (beta), 95% confidence intervals (CI), and P-values for five core SNPs and expression of the eight 17q12–21 genes that are expressed in PBMCs (A) and upper airway epithelial cells (B).

The effect sizes (beta) reflect the expected increase in expression associated with each copy of the asthma risk allele. P-values were corrected for 40 tests (5 SNPs x 8 genes); P < 0.0012 are considered significant (shown in bolded font) (also see Figure 2).

A. PBMCs (n=85)

SNP

PGAP3

ERBB2

MIEN1

GRB7

Beta

95% CI

P-value

Beta

95% CI

P-value

Beta

95% CI

P-value

Beta

95% CI

P-value

rs12936231

1·00

0·96, 1·041

0·81

0·976

0·91, 1·037

0·55

0·994

0·96, 1·024

0·99

1·02

0·82, 1·25

0·70

rs2305480

1·01

0·95, 1·084

0·62

1.0

0·89, 1·11

0·91

0·987

0·93, 1·040

0·68

0·973

0·67, 1·40

0·92

rs7216389

0·98

0·93, 1·042

0·55

0·945

0·86, 1·036

0·32

0·993

0·95, 1·038

0·90

0·888

0·65, 1·21

0·53

rs4065275

0·98

0·95, 1·026

0·49

0·992

0·93, 1·057

0·96

1·008

0·97, 1·039

0·39

1·032

0·83, 1·27

0·61

rs8076131

1·00

0·95, 1·064

0·84

0·942

0·85, 1·033

0·28

0·99

0·94, 1·035

0·8

0·943

0·69, 1·29

0·78

SNP

IKZF3

GSDMB

ORMDL3

GSDMA

Beta

95% CI

P-value

Beta

95% CI

P-value

Beta

95% CI

P-value

Beta

95% CI

P-value

rs12936231

0·967

0·91, 1·027

0·52

1·238

1·15, 1·32

<0.0001

1·186

1·12, 1·24

<0.0001

1·202

0·91, 1·58

0·23

rs2305480

0·938

0·84, 1·045

0·27

1·218

1·067, 1·39

0.0025

1·232

1·11, 1·35

<0.0001

1·279

0·78, 2·094

0·33

rs7216389

0·915

0·83, 1·001

0·17

1·239

1·11, 1·38

0.0004

1·203

1·10, 1·30

<0.0001

1·279

0·84, 1·93

0·32

rs4065275

1·003

0·94, 1·068

0·44

1·185

1·10, 1·27

<0.0001

1·133

1·071, 1·19

<0.0001

1·067

0·80, 1·42

0·79

rs8076131

0·94

0·85, 1·029

0·38

1·158

1·034, 1·29

0·021

1·151

1·058, 1·25

0.0026

1·408

0·92, 2·13

0·14

B. Upper Airway Epithelial Cells (n=246)

SNP

PGAP3

ERBB2

MIEN1

GRB7

Beta

95% CI

P-value

Beta

95% CI

P-value

Beta

95% CI

P-value

Beta

95% CI

P-value

rs12936231

1·026

0·989, 1·064

0·17

0·993

0·970, 1·016

0·54

1·009

0.993, 1.025

0·25

0·949

0.899, 1.002

0·061

rs2305480

1·147

1.081, 1.216

<0.0001

1·031

0.992, 1.071

0·12

1·016

0.991, 1.042

0·22

0·980

0.895, 1.074

0·67

rs7216389

1·081

1.032, 1.133

0.0010

1·028

0.998, 1.060

0·070

1·018

0.998, 1.039

0·070

0·990

0.921, 1.064

0·78

rs4065275

1·034

0.997, 1.072

0·74

1·008

0.985, 1.032

0·49

1·003

0.988, 1.019

0·67

1·003

0.949, 1.060

0·93

rs8076131

1·107

1.052, 1.164

<0.0001

1·028

0.995, 1.063

0·093

1·014

0.993, 1.036

0·20

0·971

0.898, 1.050

0·46

SNP

IKZF3

GSDMB

ORMDL3

GSDMA

Beta

95% CI

P-value

Beta

95% CI

P-value

Beta

95% CI

P-value

Beta

95% CI

P-value

rs12936231

0·872

0.799, 0.951

0.0021

1·026

0.975, 1.080

0·32

0·989

0.962, 1.017

0·45

0·908

0.741, 1.112

0·35

rs2305480

0·976

0.850, 1.119

0·73

1·353

1.251, 1.464

<0.0001

0·990

0.945, 1.036

0·66

1·275

0.911, 1.785

0·16

rs7216389

0·971

0.874, 1.078

0·58

1·144

1.073, 1.220

<0.0001

1·015

0.979, 1.051

0·43

1·398

1.078, 1.813

0·11

rs4065275

0·913

0.843, 0.989

0·026

1·054

1.003, 1.108

0·038

1·006

0.979, 1.035

0·65

0·962

0.786, 1.178

0·71

rs8076131

0·985

0.877, 1.105

0·79

1·225

1.144, 1.312

<0.0001

0·994

0.956, 1.034

0·78

1·328

0.998, 1.767

0·051