TABLE I.

Host Response Evaluation^a,b

	Granulation Tissue			Foreign Body Reaction			Fibrous Encapsulation
	2 weeks	2 months	5 months	2 weeks	2 months	5 months	2 weeks	2 months	5 months
EDC/NHS	2 ± 0.82	4 ± 0	2 ± 0	3.25 ± 0.96	4 ± 0	4 ± 0	2 ± 0	2 ± 0	2 ± 0
Genipin	2.25 ± 0.96	2.8 ± 0.84	1 ± 0	3.75 ± 0.5	3 ± 0	3.67 ± 0.58	2.5 ± 0.58	4 ± 0	3.33 ± 0.58
Prolene	1 ± 0	0.8 ± 0.45	1 ± 0	2 ± 0	2 ± 0	2 ± 0	3 ± 0	3.2 ± 0.45	3.75 ± 0.5
Xenmatrix	0.25 ± 0.5	0 ± 0	0 ± 0	2.5 ± 0.58	2 ± 0	2 ± 0	3 ± 0	4 ± 0	4 ± 0

^aParameters were defined as follows: granulation tissue: a precursor to fibrous tissue formation, indicated by the presence of macrophages, blood vessels and fibroblasts; foreign body response: indicated by the presence of foreign body giant cells, macrophages and monocytes; fibrous encapsulation: indicated by the presence of acellular collagen around the perimeter of mesh materials. Acute and chronic inflammation scores were zero for all but two ECC meshes (one at 2 weeks and one at 2 months); thus, inflammation scores are not included in the table

^bScoring for host response parameters reported as the mean ± SD of scores at 2 weeks, 2 months and 5 months. Scores were given on a scale from 0 to 4; 0 = no presence of host response characteristic, 1 = minimal presence, 2 = mild presence, 3 = moderate presence and 4 = extensive presence. Parameters were measured at the perimeter of mesh materials. N = 5 slides were scored in total for each parameter for each mesh type at each time point, or 1 slide per explanted sample from each animal at each time point.