Table 1.
Subgroup analysis of the any grade adverse events
| Experimental vs. control | No. of studies | RR | 95% CI | p | Heterogeneity |
|---|---|---|---|---|---|
| (I2) (%) | |||||
| Any grade adverse events | 8 | 1.04 | 0.99–1.10 | 0.16 | 97 |
| Any grade abdominal pain | 9 | 0.97 | 0.84–1.12 | 0.68 | 36 |
| Any grade anemia | 9 | 3.40 | 1.86–6.19 | < 0.001 | 95 |
| Any grade arthralgia | 7 | 0.94 | 0.82–1.07 | 0.32 | 0 |
| Any grade constipation | 9 | 1.16 | 0.91–1.49 | 0.22 | 75 |
| Any grade decreased appetite | 6 | 1.45 | 1.21–1.74 | < 0.001 | 7 |
| Any grade diarrhea | 8 | 1.23 | 1.07–1.40 | 0.003 | 20 |
| Any grade dizziness | 6 | 1.46 | 1.11–1.94 | 0.008 | 36 |
| Any grade fatigue | 9 | 1.36 | 1.20–1.53 | < 0.001 | 65 |
| Any grade headache | 8 | 1.35 | 1.04–1.74 | 0.02 | 68 |
| Any grade nausea | 9 | 1.71 | 1.35–2.17 | < 0.001 | 92 |
| Any grade neutropenia | 8 | 1.88 | 1.23–2.87 | 0.003 | 89 |
| Any grade thrombocytopenia | 7 | 3.59 | 1.65–7.78 | 0.001 | 91 |
| Any grade vomiting | 9 | 1.82 | 1.48–2.23 | < 0.001 | 60 |