Table 1.
Demographic and Clinical Characteristics of Older Adults With AF Treated With DOACs in Relation to Appropriateness of DOAC Dosing: SAGE‐AF
| Recommended Dose of DOAC (n=355) | Off‐Label Dose of DOAC (n=105) | P Value | |
|---|---|---|---|
| Age, mean (SD), y | 73.8 (6.3) | 76.6 (6.5) | <0.001* |
| Women | 167 (47.0) | 57 (54.3) | 0.19 |
| Non‐Hispanic white | 291 (82.0) | 86 (81.9) | 0.99 |
| Married or living as married | 212 (59.7) | 53 (50.5) | 0.10 |
| College graduate or above | 162 (45.6) | 42 (40.0) | 0.37 |
| Insurance status | |||
| Commercial | 45 (12.7) | 10 (9.5) | ··· |
| Medicare | 260 (73.2) | 85 (81.0) | 0.12 |
| Other | 49 (13.8) | 10 (9.5) | 0.48 |
| AF type | |||
| Paroxysmal | 227 (63.9) | 68 (64.8) | 0.35 |
| Persistent/long‐standing, persistent | 93 (26.2) | 23 (21.9) | 0.10 |
| Permanent | 11 (3.1) | 7 (6.7) | |
| Frailty category | |||
| Nonfrail | 133 (37.5) | 39 (37.1) | ··· |
| Prefrail | 174 (49.0) | 44 (41.9) | 0.11 |
| Frail | 48 (13.5) | 22 (21) | 0.07 |
| Cognitive impairment | 136 (38.3) | 49 (46.7) | 0.13 |
| Social isolation | 53 (14.9) | 16 (15.2) | 0.94 |
| Visual impairment | 129 (36.3) | 36 (34.3) | 0.70 |
| Hearing impairment | 117 (33.0) | 40 (38.1) | 0.33 |
| Depression | 99 (27.9) | 32 (30.5) | 0.61 |
| Anxiety | 89 (25.1) | 27 (25.7) | 0.89 |
| CHA2DS2‐VASc score, mean (SD) | 4.2 (1.6) | 4.7 (1.9) | 0.02* |
| HAS‐BLED score, mean (SD) | 2.8 (1.0) | 2.9 (1.0) | 0.40 |
| Medical history | |||
| Heart failure | 115 (32.4) | 43 (41.0) | 0.11 |
| Peripheral vascular disease | 42 (11.8) | 14 (13.3) | 0.68 |
| Hypertension | 316 (89.0) | 94 (89.5) | 0.88 |
| Diabetes mellitus | 104 (29.3) | 36 (34.3) | 0.33 |
| Major bleeding | 66 (18.6) | 29 (27.6) | 0.04* |
| Gastrointestinal bleeding | 37 (10.4) | 16 (15.2) | 0.94 |
| Stroke | 29 (8.2) | 11 (10.5) | 0.46 |
| Anemia | 92 (25.9) | 27 (25.7) | 0.97 |
| Chronic lung disease | 99 (27.9) | 24 (22.9) | 0.31 |
| Renal failure | 74 (20.9) | 37 (35.2) | 0.003* |
| Fall in the past 6 mo | 68 (19.2) | 22 (21.0) | 0.68 |
| Provider type | |||
| Cardiologist | 113 (31.8) | 26 (24.8) | 0.44 |
| Electrophysiologist | 236 (66.5) | 77 (73.3) | 0.71 |
| Internist | 6 (1.7) | 2 (1.9) | |
| Site | |||
| Massachusetts | 220 (62.0) | 55 (52.4) | ··· |
| Georgia | 135 (38.0) | 50 (47.6) | 0.08 |
| Aspirin use | 82 (23.1) | 19 (18.1) | 0.28 |
| Other antiplatelet use | 23 (6.5) | 9 (8.6) | 0.46 |
Continuous variables are presented as mean±SD and categorical variables as number (percentage). AF indicates atrial fibrillation; DOAC, direct‐acting oral anticoagulant; SAGE‐AF, Systematic Assessment of Geriatric Elements in Atrial Fibrillation.
*
P<0.05.