Table 2.
Frequency of Drug‐Drug Interactions by DOAC Prescribed in Older Patients With AF: SAGE‐AF
| Amiodarone | Diltiazem | Verapamil | Dronedarone | Erythromycin | Ketoconazole | Cyclosporine | Tacrolimus | Naproxen | |
|---|---|---|---|---|---|---|---|---|---|
|
Apixaban n=235 |
10 (4) | 28 (12) | 5 (2) | 4 (2) | 1 (<1) | 4 (2) | 0 | 2 (2) | 7 (3) |
| Rivaroxaban n=181 | 12 (7) | 21 (12) | 3 (2) | 1 (1) | 0 | 4 (2) | 0 | 0 | 4 (2) |
|
Dabigatran n=40 |
3 (8) | 3 (8) | 0 | 0 | 0 | 0 | 1 (3) | 0 | 1 (3) |
|
Edoxaban n=4 |
1 (25) | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
|
Total N=460 |
26 (6) | 52 (11) | 8 (2) | 5 (1) | 1 (<1) | 8 (2) | 1 (<1) | 2 (<1) | 12 (3) |
Continuous variables are presented as mean±SD and categorical variables as number (percentage). AF indicates atrial fibrillation; DOAC, direct‐acting oral anticoagulant; SAGE‐AF, Systematic Assessment of Geriatric Elements in Atrial Fibrillation.