Table 3.
Demographic, Clinical, and Geriatric Elements in Relation to Potentially Inappropriate Dosing of DOACs: SAGE‐AF
| Geriatric Elements | Unadjusted OR (95% CI) | Adjusted OR (95% CI) |
|---|---|---|
| Age | 1.1 (1.0, 1.1) | 1.1 (1.0, 1.1)* |
| History of renal failure | 2.1 (1.3, 3.3) | 1.8 (1.1, 3.0)* |
| History of major bleeding | 1.7 (1.0, 2.8) | 1.5 (0.9, 2.5) |
| CHA2DS2‐VASc score | 1.2 (1.0, 1.3) | 1.1 (1.0, 1.3)* |
| Frailty | 1.6 (0.8, 2.9) | 1.2 (0.6, 2.3) |
| Cognitive impairment | 1.4 (0.9, 2.2) | 1.1 (0.7, 1.8) |
| Social isolation | 1.0 (0.6, 1.9) | 1.0 (0.6, 1.9) |
| Visual impairment | 0.9 (0.6, 1.4) | 0.8 (0.5, 1.3) |
| Hearing impairment | 1.3 (0.8, 2.0) | 1.2 (0.7 1.9) |
| Elevated depressive symptoms | 1.1 (0.7, 1.8) | 1.1 (0.7, 1.7) |
DOAC indicates direct‐acting oral anticoagulant; OR, odds ratio; SAGE‐AF, Systematic Assessment of Geriatric Elements in Atrial Fibrillation.
*
P<0.05.