Table 1.
CPET Parameters Before and After Supplementation of Medication With AkP05 or a Diuretic
| Variable | AkP05 Group (n=12) | Measured Effect Size | Diuretic Group (n=12) | Measured Effect Size | ||||
|---|---|---|---|---|---|---|---|---|
| Before | After | P Value | Before | After | P Value | |||
| SBP rest, mm Hg | 136.1±10.5 | 124.6±11.7 | 0.0016 | −1.08 | 138.33±7.0 | 127.5±12.6 | >0.0001 | −1.91 |
| SBPMAX, mm Hg | 176.5±18.9 | 153.8±14.4 | 0.0031 | −0.97 | 175.6±16.8 | 182.9±11.4 | 0.1261 | 0.35 |
| DBP rest, mm Hg | 87.5±11.0 | 85.0±8.7 | 0.2030 | −0.25 | 88.3±14.9 | 87.3±10.9 | 0.4175 | −0.06 |
| DBPMAX, mm Hg | 110.7±12.1 | 103.1±14.5 | 0.0379 | −0.57 | 112.0±6.6 | 107. 8±11.3 | 0.1491 | −0.32 |
| METs, rest | 1.36±0.2 | 1.52±0.5 | 0.0947 | 0.40 | 1.3±0.4 | 1.5±0.5 | 0.1318 | 0.34 |
| METs, max | 8.4±1.8 | 8.7±1.6 | 0.0539 | 0.64 | 8.1±1.1 | 8.2±1.6 | 0.4534 | 0.03 |
| VO2/kg, rest (mL/min per kg) | 4.3±0.7 | 4.9±1.4 | 0.0930 | 0.41 | 4.2±1.0 | 4.3±1.0 | 0.3705 | 0.10 |
| VO2/kg, MAX (mL/min per kg) | 27.6±2.7 | 31.3±3.2 | >0.0001 | 1.80 | 28.0±3.3 | 27.7±3.3 | 0.1126 | −0.37 |
| Exercise duration (min) | 12.6±4.3 | 15.8±4.3 | 0.0050 | 0.90 | 12.3±1.5 | 12.1±2.0 | 0.3579 | −0.11 |
| Max. power (W) | 175.3±33.5 | 208.3±41.6 | 0.0219 | 1.46 | 176.9±28.1 | 168.1±32.8 | 0.0148 | −0.72 |
| FVC | 4.24±0.6 | 4.3±0.8 | 0.2044 | 0.25 | 4.4±0.8 | 4.4±0.8 | 0.4514 | 0.04 |
| FEV | 3.4±0.6 | 3.4±0.6 | 0.3966 | −0.08 | 3.4±0.3 | 3.3±0.3 | 0.0646 | −0.47 |
Data are mean±SD. Statistical analysis was performed using paired t test between before/after in the same patients’ group. Measured effect size was calculated by G*Power 3.1.9.4. CPET indicates cardiopulmonary exercise test; DBP rest, diastolic blood pressure measured at rest; DBPMAX, maximal diastolic blood pressure; FEV, forced expiratory volume in 1 second; FVC, forced vital capacity; Max. power (W), maximal power output; METs MAX, maximal 1 metabolic equivalent; METs rest, 1 metabolic equivalent measured at rest; SBP rest, systolic blood pressure measured at rest; SBPMAX, maximal systolic blood pressure; VO2/kg MAX, maximal respiratory oxygen uptake; VO2/kg rest, respiratory oxygen uptake measured at rest.