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. 2020 Feb 20;9(5):e014142. doi: 10.1161/JAHA.119.014142

Figure 3.

Figure 3

Renal injury and T‐cell infiltration in SHR‐A3, SHR‐B2 and SHR‐A3(Stim1‐B2). A, Glomerular (Glom) and tubulointerstitial (TI) injury scores, n=8 (SHR‐A3), 18 (SHR‐B2), 10 (SHR‐A3[Stim1‐B2]). B, Urinary renal injury biomarker levels for neutrophil gelatinase‐associated lipocalin (NGAL), osteopontin (OPN), and kidney injury molecule‐1 (KIM‐1) normalized to creatinine excretion in urine collected from 30‐week‐old SHR‐A3, SHR‐B2, and SHR‐A3(Stim1‐B2) rats, n=8. C, Urinary albumin excretion normalized to urinary creatinine in 40‐week‐old SHR‐A3, SHR‐B2, and SHR‐A3(Stim1‐B2) rats; n=23 (SHR‐A3), 19 (SHR‐B2), 14 (SHR‐A3[Stim1‐B2]). *P<0.05 vs SHR‐A3 and # P<0.05 vs SHR‐B2. Flow cytometric analysis of (D) T and B cells, (E) CD4+ and CD8+ T‐cell subsets, and (F) Tregs in kidneys from 40‐week‐old SHR‐A3, SHR‐B2, and SHR‐A3(Stim1‐B2) rats; n=5 rats. *P<0.05 vs SHR‐A3 and # P<0.05 vs SHR‐B2. Treg indicates regulatory T cells; uACR, urinary albumin/creatinine ratio.