Table 2. Significant signaling pathways based on KEGG database.

KEGG ID	Category	Genes in Pathway	P-value
04066	HIF1 signaling	HIF1α, VEGFA, FLT1, ANG1, ANG2, NFĸB1, RELA, BCL2, IL6	2.1e-8
04668	TNF signaling	TNF, NFkB1, IL1β, RELA, CXCL1, CXCL3, CCL20, IL6	7.7e-7
04064	NF kappa B signaling	NFĸB1, NFĸB2, TNF, RELA, CCL19, IL1β, BCL2,	2.0e-7
05202	Misregulation in cancer	IL3, IL6, CCR7, RELA, IL1β, NFĸB1	1.4e-6

Abbreviations: KEGG, Kyoto encyclopedia of genes and genomes.