Table 2.

The Common Central Nervous System (CNS) and Peripheral Nervous System (PNS) Adverse Effects of Drugs Used in COVID-19 Management

Drug	CNS Adverse Reactions	PNS Adverse Reactions
Chloroquine (CQ)	Acute confusional state,28 delirium,29 decreased deep tendon reflex, depression, extrapyramidal disorders,30 seizure31	Myopathy,32 neuromuscular disease, polyneuropathy
Hydroxychloroquine (HCQ)	Ataxia, vertigo, dizziness, sensorineural hearing loss, neurosis, psychosis, seizure	Myopathy33
Umifenovir	Dizziness, psychiatric symptoms (0.83%)34
Lopinavir/Ritonavir	Fatigue, headache, anxiety (4%), insomnia	Weakness, myalgia
Interferon alpha	Fatigue, headache, depression, drowsiness (1 to 33%), dizziness, vertigo, malaise, paresthesia, confusion (≤12), insomnia	Myalgia, asthenia, musculoskeletal pain, arthralgia, back pain
Favipiravir	Psychiatric reactions (1.72%)34
Remdesivir	Have not reported yet.	Have not reported yet.
Tocilizumab	Headache, dizziness (rare)	Chronic inflammatory demyelinating polyneuropathy (<1%)
Corticosteroids	Psychosis (14%),35,36 mania (28%), depression (41%), delirium,36 anxiety,36 insomnia,36 seizure, vertigo, paresthesia,37 pseudotumor cerebri38,39	Myopathy,40 neuropathy41,42