Table 1.

Level of Evidence and Grade of Recommendations.

Level of evidence		Confidence in the evidence
1. High	Data derived from meta-analyses or systematic reviews or from (multiple) randomized trials with high quality.	Further research is unlikely to change our confidence in the estimate of benefit and risk.
2. Moderate	Data derived from a single RCT or multiple nonrandomized studies.	Further research (if performed) is likely to have an impact on our confidence in the estimate of benefit and risk and may change the estimate.
3. Low	Small studies, retrospective observational studies, registries.	Any estimate of effect is uncertain.
Recommendations – Grade		Wording associated with the grade of recommendation
1. Strong		‘‘must”, ‘‘should”, or ‘‘INASL recommends”
2. Weak		‘‘can”, ‘‘may”, or ‘‘INASL suggests”

Adapted from GRADE system.

GRADE, Grading of Recommendations Assessment Development and Evaluation; INASL, Indian National Association for the Study of the Liver; RCT, randomized controlled trial.