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. 2020 Apr 28;10(4):339–376. doi: 10.1016/j.jceh.2020.04.012

Table 3.

Definitions of Acute Liver Failure Used in Clinical Practice

Author Encephalopathy Coagulopathy Jaundice encephalopathy interval
Trey & Davidson1 Any grade INR >1.5 8 weeks
AASLD (Lee)2 Any grade INR > 1.5 or PT > 15sec 26 weeks
O'Grady19 Any grade INR > 1.5 12 weeks
IASL (Tandon)20 Any grade INR > 1.5 4 weeks
Japanese (Yamagishi)21 Any grade PTA <40% 8 weeks

Numbers in superscript indicate the reference number. INR, international normalized ratio; PT, prothrombin time; PTA, plasma thromboplastin antecedent.

INR, international normalized ratio; PT, prothrombin time; PTA, Plasma Thromboplastin Antecedent.