Figure 4.

Characterization of Patient-Derived Therapeutic iNSCs

(A) Following transdifferentiation, marked patient-specific variation was again revealed by PCA and a Pearson correlation heatmap. (B) A heatmap revealing the most highly differentially expressed genes between model iNSC line derived from NHF1 and each patient-specific iNSC line. (C) Boxplot comparison of fibroblasts and induced neural stem cell lines. The PF represent the log2 signal across patient-derived fibroblasts and the NHF1 cell line. The iNSC represents the log2 signal across patient-derived iNSCs and the iNSC cell line for SOX2, NEUROG2, NANOG, ASCL1, POU5F1, and PAX6.