Table 1.
Descriptive statistics of samples with complete phenotype and genotype data.
| AGP | DE | P | Merged | |
|---|---|---|---|---|
| N total | 1895 | 614 | 2509 | |
| Age at diag. in months, mean (SD) | 103.11 (58.52) | 128.72 (74.19) | <0.001a | 109.38 (63.66) |
| Male gender, N (%) | 1649 (87.02%) | 525 (85.50%) | 0.373b | 2174 (86.64%) |
| Female gender, N (%) | 246 (12.98%) | 89 (14.50%) | 335 (13.35%) | |
| IQ, mean (SD) | 78.63 (24.44) | 88.96 (23.30) | <0.001a | 80.99 (24.56) |
| IQ > 70, N (%) | 1145 (60.42%) | 418 (74.51%) | <0.001b | 1563 (62.29%) |
| IQ ≤ 70, N (%) | 750 (39.58%) | 143 (25.50%) | 893 (35.59%) | |
| Subdomains, mean (SD) | ||||
| Social interaction (SI) | 10.17 (3.24) | 10.30 (3.43) | 0.180a | 10.20 (3.29) |
| Joint attention (JA) | 12.86 (4.63) | 11.92 (5.02) | <0.001a | 12.63 (4.74) |
| Peer interaction (PI) | 7.31 (2.56) | 7.30 (2.79) | 0.815a | 7.31 (2.61) |
| Nonverbal communication (NVC) | 4.14 (2.24) | 4.37 (2.21) | 0.023a | 4.19 (2.23) |
| Repetitive sensory-motor behavior (RB) | 6.04 (2.97) | 5.16 (3.25) | <0.001a | 5.83 (3.07) |
| Restricted interests (RI) | 3.08 (2.03) | 2.91 (1.90) | 0.103a | 3.04 (2.00) |
DE German cohort, AGP Autism Genome Project cohort, diag. diagnosis, SD standard deviation.
aWilcoxon test.
bChi-square test.
P: nominal P value comparing DE versus AGP cohort.