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Dual Function of CAR 4 T Cells
41BB-costimulated CAR 4 T cells recognize the HIV envelope expressing infected cells through the CD4 protein, which constitutes part of the CAR. These cells can directly kill infected target cells through the secretion of perforin and granzyme A and B. The cytokines produced by these CAR 4 T cells also lead to the enhanced survival, proliferation, and effector function of CAR 8 T cells.
