Table 1.
Patient Characteristics and Correlation Between Clinical Features and MET Exon 14 Skipping in NSCLC Patients
| Clinical Features | No. (n=951) | Met ex14 Skipping | P-value | ||
|---|---|---|---|---|---|
| Negative N=935 (98.3%) | Positive N=16 (1.7%) | ||||
| Age (years) | ≥ 60 | 626 | 611 (97.6%) | 15 (2.4%) | 0.018 |
| < 60 | 325 | 324 (99.7%) | 1 (0.3%) | ||
| Gender | Male | 526 | 515 (97.9%) | 11 (2.1%) | 0.275 |
| Female | 425 | 420 (98.8%) | 5 (1.2%) | ||
| Smoking history | Never-smoker | 454 | 447 (98.5%) | 7 (1.5%) | 0.551 |
| Ever-smoker | 434 | 425 (97.9%) | 9 (2.1%) | ||
| Unknown | 63 | 63 (100%) | 0 (0%) | ||
| Location | Left lung | 394 | 384 (97.5%) | 10 (2.5%) | 0.053 |
| Right lung | 539 | 534 (99.1%) | 5 (0.9%) | ||
| Unknown | 18 | 17 (94.4%) | 1 (5.6%) | ||
| Stage | I–III | 232 | 226 (97.4%) | 6 (2.6%) | 0. 756 |
| IV | 376 | 369 (98.1%) | 7 (1.9%) | ||
| Unknown | 343 | 340 (99.1%) | 3 (0.9%) | ||
| Histological subtypes | Adenocarcinoma | 772 | 758 (98.2%) | 14 (1.8%) | 0.015 |
| Squamous | 151 | 151 (100%) | 0 (0.0%) | ||
| Adenosquamous | 11 | 10 (90.9%) | 1 (9.1%) | ||
| Sarcomatoid carcinoma | 4 | 3 (75.0%) | 1 (25.0%) | ||
| Others | 13 | 13 (100%) | 0 (0%) | ||
| PD-L1 (TPS) | < 50% | 328 | 324 (98.8%) | 4 (1.2%) | <0.001 |
| ≥ 50% | 77 | 68 (88.3%) | 9 (11.7%) | ||
| c-MET IHC | 0 | 33 | 33 (100%) | 0 (0.0%) | 0. 152 |
| 1+ | 122 | 121 (99.2%) | 1 (0.8%) | ||
| 2+ | 160 | 157 (98.1%) | 3 (1.9%) | ||
| 3+ | 49 | 46 (93.9%) | 3 (6.1%) | ||
| unknown | 587 | 578 (98.5%) | 9 (1.5%) | ||