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. 2020 Jun 30;12:5085–5098. doi: 10.2147/CMAR.S242135

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© 2020 Li et al.

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Sev inhibited glioma progression by regulating circ_0002755. (A and B) Circ_0002755 level was detected in A-172 and SHG-44 cells transfected with vector or circ_0002755 by qRT-PCR assay. (C and D) The level of circ_0002755 in glioma cells treated with Sev or Sev + circ_0002755, as well as corresponding controls was detected by qRT-PCR. (E and F) The viability of glioma cells was checked by CCK8 assay. (G and H) Flow cytometry assay was used to check the apoptosis of glioma cells. (I and J) The protein levels of Bcl-2, Bax and cleaved caspase 3 in samples were determined by Western blot. (K–N) The abilities of cell migration and invasion were estimated by transwell assay. (O–R) The rates of glucose consumption and lactate production were evaluated by glucose colorimetric assay kit and lactate colorimetric assay kit, respectively. (S and T) The protein level of HK2 in glioma cells under different conditions was checked by Western blot. **P< 0.01. ***P< 0.001. ****P< 0.0001.