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. 2020 Jun 30;12:5085–5098. doi: 10.2147/CMAR.S242135

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© 2020 Li et al.

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Circ_0002755/miR-628-5p axis functioned in Sev-mediated glioma progression. (A and B) The level of miR-628-5p in glioma cells treated with Sev, Sev + circ_0002755 or Sev + circ_0002755 + miR-628-5p, as well as matched controls was detected by qRT-PCR. (C and D) CCK8 assay was executed to check cell viability. (E and F) Cell apoptosis was checked by flow cytometry. (G and H) Western blot was conducted to measure the protein levels of Bcl-2, Bax and cleaved caspase 3 in samples. (I–L) Transwell assay was utilized to assess the abilities of cell migration and invasion. (M–P) The rates of glucose uptake and lactate production were detected by corresponding colorimetric assay kit. (Q and R) Western blot was utilized to determine the protein level of HK2 in samples. *P< 0.05, **P< 0.01. ***P< 0.001. ****P< 0.0001.