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. 2020 Jun 24:1–15. doi: 10.1080/07391102.2020.1784289

Table 3.

Binding interaction of different bioactive herbal ligands with the active site of SARS-CoV-2 NSP15 endoribonuclease (PDB ID: 6W01).

S. No. Ligand Interaction (PDB-6M0J)
H-Bonding No. of H-Bond
HBD HBA
1 Asparoside-C Glu 234, Gly 230, Val 292, Hip 235, Asp 240 5 3
2 Asparoside-F Glu 234, Gly 230, Ala 232, Hip 235, Asp 240, Glu 340, Val 339 5 3
3 Asparoside-D Glu 340, His 243, Gln 245, Asp 240, Asn 278, Leu 346 6 1
4 Rutin Asp 240, Gln 245, Hip 235, Hip 250, Glu 340 4 3
5 Racemoside-A Thr 341, Hip 235, Glu 340, Hip 250 3 3
6 Remdesivir Val 292, Hip 235, Thr 341 1 2

H-Bond: Hydrogen Bonding, HBD: Hydrogen bond donor, HBA: Hydrogen bond acceptor in respect to ligand.