Table 1.
Characteristics of miRNAs in UM
| miRNA | Target | Expression | Mechanism | Sample | Role | Reference |
|---|---|---|---|---|---|---|
| miR-137 | c-Met, CDK6, MITF, p160 SRCs | Down | Inhibit cell proliferation | Cell lines (M17, M23, SP6.5, OCM-1/3, OMM1/1.3, Mel202, 92.1) | Tumor suppressor | 19,20 |
| miR-145 | IRS-1 | Down | Inhibit cell proliferation and promote apoptosis | Tissues and cell lines (OCM-1, MUM-2B) | Tumor suppressor | 21 |
| miR-144 | c-Met | Down | Inhibit cell proliferation and invasion | Tissues and cell lines (OCM-1A, MUM-2B/2C, C918) | Tumor suppressor | 22 |
| miR-92a-3p | MYCBP2 | Up | Inhibit apoptosis | Cell lines (OCM-1/3, 92.1) | Oncogenic | 23 |
| miR-181b | CTDSPL | Up | Promote cell cycle progression | Tissues and cell lines (SP6.5, VUP, OCM-1/1A, MUM-2B, 92.1) | Oncogenic | 24 |
| miR-296-3p | MMP-2, MMP-9 | Down | Inhibit cell proliferation, migration, invasion and promote apoptosis | Tissues and cell lines (C918) | Tumor suppressor | 25 |
| miR-20a | Not reported | Up | Promote cell proliferation, migration and invasion | Tissues and cell lines (MUM-2B/2C) | Oncogenic | 26 |
| miR-155 | NDFIP1 | Up | Promote cell proliferation and invasion | Tissues and cell lines (OCM-1A, MUM-2B/2C, C918) | Oncogenic | 27 |
| miR-454 | PTEN | Up | Promote cell proliferation, invasion, colony formation and cell cycle progression | Tissues and cell lines (OCM-1A, MUM-2B/2C, C918) | Oncogenic | 28 |
| miR-367 | PTEN | Up | Promote cell proliferation and migration | Tissues and cell lines (M17/23, MUM-2B, C918) | Oncogenic | 29 |
| miR‐224‐5p | PIK3R3/AKT3 | Down | Inhibit cell proliferation, migration and invasion | Tissues and cell lines (OCM-1A) | Tumor suppressor | 30 |
| miR-21 | p53 | Up | Promote cell proliferation, migration and invasion | In vivo (BALB/c) and cell lines (OCM-1A) | Oncogenic | 31 |
| miR-23a | Zeb1 | Down | Inhibit cell migration | Cell lines (OCM-1) | Tumor suppressor | 34 |