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. 2020 Jul 1;12:5243–5254. doi: 10.2147/CMAR.S237323

Figure 2.

Figure 2

Effects of Honokiol on the cell apoptosis, cell cycle and cell invasion of pancreatic cancer cells. (A, B) Caspase-3 activity of PANC-1 and SW1990 cells after being treated with 50 µM Honokiol or vehicle for 24 h was determined by Caspase-3 activity Assay Kit. (C, D) Active caspase-3, caspase-9 and Bax protein levels of PANC-1 and SW1990 cells after being treated with 50 µM Honokiol or vehicle for 24 h was determined by Western blot assay. (E–H) Flow cytometry determined cell apoptotic rates (E, F) and cell cycle (G, H) of PANC-1 and SW-1990 cells after being treated with 50 µM Honokiol or vehicle for 24 h. (I, J) Transwell invasion assay determined cell invasive ability of PANC-1 and SW1990 cells after being treated with 50 µM Honokiol or vehicle for 24 h. N = 3. *P<0.05 and **P<0.01.