Figure 4.

The relations between the variance of the mean first passage times $\left({\sigma }_{T_1}\right)$ and the ligand potency (EC₅₀). The kinetic parameters k_on and k_off and the ligand potency EC₅₀ used to evaluate τ_N are taken from (32) (for the top plot) and from (7) (for the bottom plot). These data are also presented in the Supporting Materials and Methods. In calculations, N = 6 and k_p = 0.1 s⁻¹ were utilized as suggested in (9) and (22). To see this figure in color, go online.