Figure 5.

The dependence of speed, specificity, and selectivity of T cell activation on the number of phosphorylation steps. (a) shows the speed for k_p = 1 s⁻¹, k_off = 0.10 × k_p, and k_on = 10 s⁻¹; (b) shows the sensitivity for k_p = 1 s⁻¹, k_off = 0.10 × k_p, and k_on = 100 s⁻¹; and (c) shows the specificity for k_p = 1 s⁻¹, $k_{off}^{\left(\text{foreign}\right)}$ = 0.10 × k_p, $k_{off}^{\left(\text{self}\right)}$ = 10 × k_p, $k_{on}^{\left(\text{foreign}\right)}$ = 1 s⁻¹, and $k_{on}^{\left(\text{self}\right)}$ = 1000 s⁻¹. To see this figure in color, go online.