Table 1.
Cohort demographics, clinical characteristics, and laboratory data at biopsy
| Cohort characteristics | Proteinuria <0.5 g/d (n = 46) | Proteinuria ≥0.5 g/d (n = 176) | P valuea |
|---|---|---|---|
| Female | 36 (78.3) | 155 (88)a | 0.097 |
| Age, yr | 31.5 (18–65) | 32 (16–66) | 0.72 |
| Duration of lupus, mo | 12 (2–60) | 11 (1–168) | 0.64 |
| Glomerular hematuria present | 46 (100) | 169 (96) | 0.36 |
| Proteinuria, g/d | 0.23 (0.0–0.42) | 3.60 (0.5–20) | <0.0001 |
| Serum creatinine, mg/dl | 0.70 (0.4–1.3) | 0.9 (0.46–7.8) | <0.0001 |
| ANA-positive, | 46 (100) | 176 (100) | — |
| Anti-dsDNA–positive | 31 (67.4) | 114 (64.8) | 1 |
| C3, mg/dl | 66 (15–174) | 69 (14–180) | 0.97 |
| C4, mg/dl | 12 (1–43) | 9 (1–46) | 0.89 |
ANA, anti-nuclear antibody; anti-dsDNA, anti−double-stranded DNA antibody; C3, complement C3; C4, complement C4.
Data are expressed as number of patients (% of group) or median (range).
a
Comparing patients with proteinuria <0.5 g/d to patients with proteinuria ≥0.5 g/d.