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. 2020 Jun 8;119(1):190–205. doi: 10.1016/j.bpj.2020.05.030

Figure 10.

Figure 10

Reorganization of salt bridges in VSDs. (a) An example from the first simulation of NavMs under hyperpolarizing TMV showing positively charged (green) and negatively charged (magenta) residues in VSD2. All four salt-bridge connections, ARG103-ASP49, ARG106-ASP49, ARG109-GLU59, and ARG109-ASP81, broke during the pulse, and one new connection was formed: ARG106-ASP81. (b) An example showing how a Cl− ion facilitates breakage of a salt bridge between ARG109 and GLU59 in VSD4 of NavMs. Other residues are omitted from representation for clarity. Frames were taken from the second simulation under hyperpolarizing TMV. To see this figure in color, go online.