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. 2020 May 11;10(3):472–476. doi: 10.34172/apb.2020.058

Figure 1.

Figure 1

Effect of interaction of different amino acid residues of Human Multidrug Resistant Protein- 1 (RCSB PDB ID: 2CBZ) with kaempferol and verapamil, standard P-glycoprotein inhibitor. (A)The docking energy as well as the interaction energy of kaempferol was found to be 23.14 and 27.46 respectively. The light green color indicates the carbon hydrogen bond of interaction between glycine amino acid sequences and the oxygen. The interaction of kaempferol with different amino acid sequences were found to be more when compared with other selected flavonoid compounds(data not shown). (B)The docking energy as well as the interaction energy of verapamil was found to be 6.69 and 34.82 respectively. The docking energy of verapamil is comparatively less than kaempferol. It shows van der Waals force of interaction, carbon hydrogen bond interaction etc. with different amino acid sequences of human multidrug resistant protein-1.