Table 3.

Nodes efficiency of HC and PMS patients computed on the raw connectomes

	Side	HC (n = 24)	PMS (n = 42)	p a	p b
PFC	R	709.40 ± 103.54	546.64 ± 171.56	<.001	.001
	L	707.44 ± 124.48	556.60 ± 190.01	.002	.012
S2	R	401.98 ± 53.94	385.79 ± 100.87	.398	.073
	L	379.30 ± 62.29	370.41 ± 89.42	.766	.274
M2	R	434.33 ± 76.70	352.43 ± 83,17	<.001	.002
	L	401.06 ± 67.52	335.49 ± 88.80	.002	.006
As Sens C	R	620.74 ± 111.40	479.05 ± 131.44	<.001	<.001
	L	656.76 ± 110.77	492.80 ± 122.97	<.001	<.001
S‐M1	R	839.94 ± 128.53	674.43 ± 172.13	<.001	.001
	L	783.84 ± 138.19	654.77 ± 171.33	.004	.028
Deep GM	R	646.60 ± 109.95	498.40 ± 159.60	<.001	.001
	L	658.61 ± 107.49	537.86 ± 161.56	.002	.014
Cerebellum	R	163.01 ± 61.32	153.46 ± 50.50	.608	.911
	L	130.99 ± 52.71	129.97 ± 44.51	.977	.602

Abbreviations: AS Sens C, posterior associative sensory cortex; Deep GM, deep grey matter; HCs, healthy controls; M2, secondary motor cortex; S‐M1, sensory‐motor cortex; S2, secondary sensory cortex; PFC, prefrontal cortex; PMS, progressive multiple sclerosis.

Note: All values are expressed as mean ± SD; ANCOVA age and gender corrected (p ^a), ANCOVA age, gender and density corrected (p ^b). Statistically significant p values after Bonferroni correction are highlighted in bold.