Table 4.

Global graph metrics of HCs and PMS patients on COMMIT‐weighted connectomes

	HC (n = 24)	PMS (n = 42)	p a	p b
Modularity	0.41 ± 0.02	0.46 ± 0.05	<.001	.005
Global efficiency	5.27 ± 0.62	4.35 ± 0.52	<.001	<.001
Clustering coefficient	5.67 ± 0.81	5.18 ± 0.70	.024	.025
Mean strength	38.15 ± 4.22	31.64 ± 3.88	<.001	<.001
Assortativity	−0.16 ± 0.03	−0.13 ± 0.04	.006	.188
Density	0.88 ± 0.26	0.82 ± 0.09	.004	–

Abbreviations: COMMIT, convex optimization modelling for microstructure informed tractography; HCs, healthy controls; PMS, progressive multiple sclerosis.

Note: All values are expressed as mean ± SD. Raw p values from the post hoc test to compare subject groups in terms of the network metrics are reported in the last two columns; p ^a comparison controlling for age and sex; p ^b, comparison controlling for age, sex and density. Statistically significant p values after Bonferroni correction are highlighted in bold.