Table 5.
Nodes strength of HCs and PMS patients computed on COMMIT‐weighted connectomes
| Side | HC (n = 24) | PMS (n = 42) | p a | p b | |
|---|---|---|---|---|---|
| PFC | R | 53.16 ± 9.33 | 40.86 ± 8.78 | <.001 | <.001 |
| L | 54.88 ± 7.22 | 42.81 ± 10.57 | <.001 | .001 | |
| S2 | R | 22.19 ± 5.71 | 19.53 ± 4.47 | .064 | .235 |
| L | 23.20 ± 4.95 | 19.21 ± 4.66 | .002 | .011 | |
| M2 | R | 25.54 ± 6.42 | 24.68 ± 6.77 | .587 | .500 |
| L | 19.69 ± 5.61 | 18.60 ± 4.99 | .425 | .107 | |
| As Sens C | R | 31.19 ± 4.43 | 26.55 ± 6.54 | .005 | .079 |
| L | 36.77 ± 7.37 | 27.43 ± 6.34 | <.001 | <.001 | |
| S‐M1 | R | 62.95 ± 11.77 | 56.30 ± 9.03 | .027 | .129 |
| L | 62.66 ± 13.90 | 52.03 ± 8.32 | <.001 | .002 | |
| Deep GM | R | 49.71 ± 6.63 | 34.08 ± 10. 30 | <.001 | <.001 |
| L | 52.55 ± 14.48 | 36.69 ± 9.90 | <.001 | <.001 | |
| Cerebellum | R | 20.35 ± 7.87 | 22.26 ± 7.73 | .232 | .698 |
| L | 19.30 ± 7.30 | 21.88 ± 7.72 | .174 | .676 |
Abbreviations: AS Sens C, posterior associative sensory cortex; COMMIT, convex optimization modelling for microstructure informed tractography; Deep GM, deep grey matter; HCs, healthy controls; M2, secondary motor cortex; S‐M1, sensory‐motor cortex; S2, secondary sensory cortex; PFC, prefrontal cortex; PMS, progressive multiple sclerosis.
Note: All values are expressed as mean ± SD; ANCOVA age and gender corrected (p a), ANCOVA age, gender and density corrected (p b). Statistically significant p values after Bonferroni correction are highlighted in bold.