Figure 1.
Main pathways of ROS and NOS in the central nervous system. (a) Fenton reaction; (b) peroxynitrite reaction; (c) lipid peroxidation. O2·-: superoxide radical; SOD: superoxide dismutase; H2O2: hydrogen peroxide; Fe++: ferrous iron; Fe+++: ferric iron; ·OH: hydroxyl radical; OH-: hydroxyl anion; ·NO: nitric oxide or nitrogen monoxide; ·NO2: nitrogen dioxide; ONOO-: peroxynitrite anion; CO2: carbon dioxide; ONOOH: peroxynitrous acid; ONOOCO2: nitrosoperoxocarbonate; ·CO3: carbonate radical; ·R: free radical; RH: neutralized radical; LH: polyunsaturated fatty acid; ·L: alkyl radical; O2: molecular oxygen; ·LOO: peroxyl radical; LOOH: lipid hydroperoxide.