Table 1.
Information of potential targets from characteristic high-content bioactive components group of Fructus Gardeniae from Jiangxi province in China.
| Molecule | OB (%) | DL | Target | Gene | UniProt ID | Probability∗(%) |
|---|---|---|---|---|---|---|
| Geniposide | 14.64 | 0.44 | MX2 : AA81X2 : AA81microtubule-associated protein tau | MAPT | P10636 | 75.00 |
| 14.64 | 0.44 | Protein kinase C gamma type | PRKCG | P05129 | 24.00 | |
| 14.64 | 0.44 | Protein kinase C beta type | PRKCB | P05771 | 24.00 | |
| 14.64 | 0.44 | Protein kinase C alpha type | PRKCA | P17252 | 24.00 | |
| 14.64 | 0.44 | Protein kinase C theta type | PRKCQ | Q04759 | 24.00 | |
| 14.64 | 0.44 | Protein kinase C delta-type regulatory subunit | PRKCD | Q05655 | 24.00 | |
| 14.64 | 0.44 | Hypoxia-inducible factor 1-alpha | HIF1A | Q16665 | 24.00 | |
| 14.64 | 0.44 | Endothelial PAS domain-containing protein 1 | EPAS1 | Q99814 | 24.00 | |
| 14.64 | 0.44 | Bcl-2-like protein 1 | BCL2L1 | Q07817 | 18.00 | |
| 14.64 | 0.44 | Apoptosis regulator Bcl-2 | BCL2 | P10415 | 18.00 | |
| 14.64 | 0.44 | Bcl-2-like protein 2 | BCL2L2 | Q92843 | 18.00 | |
| 14.64 | 0.44 | Mu-type opioid receptor | OPRM1 | P35372 | 14.00 | |
| 14.64 | 0.44 | Delta-type opioid receptor | OPRD1 | P41143 | 14.00 | |
| 14.64 | 0.44 | Kappa-type opioid receptor | OPRK1 | P41145 | 14.00 | |
| 14.64 | 0.44 | Nociceptin receptor | OPRL1 | P41146 | 14.00 | |
|
| ||||||
| Gardenoside | 52.77 | 0.12 | Microtubule-associated protein tau | MAPT | P10636 | 68.00 |
| 52.77 | 0.12 | Protein kinase C gamma type | PRKCG | P05129 | 25.00 | |
| 52.77 | 0.12 | Protein kinase C beta type | PRKCB | P05771 | 25.00 | |
| 52.77 | 0.12 | Protein kinase C alpha type | PRKCA | P17252 | 25.00 | |
| 52.77 | 0.12 | Protein kinase C theta type | PRKCQ | Q04759 | 25.00 | |
| 52.77 | 0.12 | Protein kinase C delta-type regulatory subunit | PRKCD | Q05655 | 25.00 | |
| 52.77 | 0.12 | Hypoxia-inducible factor 1-alpha | HIF1A | Q16665 | 16.00 | |
| 52.77 | 0.12 | Endothelial PAS domain-containing protein 1 | EPAS1 | Q99814 | 16.00 | |
| 52.77 | 0.12 | Tyrosine-protein phosphatase nonreceptor type 2 | PTPN2 | P17706 | 16.00 | |
| 52.77 | 0.12 | Tyrosine-protein phosphatase nonreceptor type 1 | PTPN1 | P18031 | 16.00 | |
| 52.77 | 0.12 | Tyrosyl-DNA phosphodiesterase 1 | TDP1 | Q9NUW8 | 15.00 | |
| 52.77 | 0.12 | Mu-type opioid receptor | OPRM1 | P35372 | 14.00 | |
| 52.77 | 0.12 | Delta-type opioid receptor | OPRD1 | P41143 | 14.00 | |
| 52.77 | 0.12 | Kappa-type opioid receptor | OPRK1 | P41145 | 14.00 | |
| 52.77 | 0.12 | Nociceptin receptor | OPRL1 | P41146 | 14.00 | |
|
| ||||||
| Geniposidic acid | 19.59 | 0..41 | Microtubule-associated protein tau | MAPT | P10636 | 74.00 |
| 19.59 | 0..41 | Hypoxia-inducible factor 1-alpha | HIF1A | Q16665 | 29.00 | |
| 19.59 | 0..41 | Endothelial PAS domain-containing protein 1 | EPAS1 | Q99814 | 29.00 | |
| 19.59 | 0..41 | Protein kinase C gamma type | PRKCG | P05129 | 22.00 | |
| 19.59 | 0..41 | Protein kinase C beta type | PRKCB | P05771 | 22.00 | |
| 19.59 | 0..41 | Protein kinase C alpha type | PRKCA | P17252 | 22.00 | |
| 19.59 | 0..41 | Protein kinase C theta type | PRKCQ | Q04759 | 22.00 | |
| 19.59 | 0..41 | Protein kinase C delta-type regulatory subunit | PRKCD | Q05655 | 22.00 | |
| 19.59 | 0..41 | Tyrosyl-DNA phosphodiesterase 1 | TDP1 | Q9NUW8 | 21.00 | |
| 19.59 | 0..41 | Bcl-2-like protein 1 | BCL2L1 | Q07817 | 18.00 | |
| 19.59 | 0..41 | Apoptosis regulator Bcl-2 | BCL2 | P10415 | 18.00 | |
| 19.59 | 0..41 | Bcl-2-like protein 2 | BCL2L2 | Q92843 | 18.00 | |
| 19.59 | 0..41 | Sodium-dependent noradrenaline transporter | SLC6A2 | P23975 | 14.00 | |
| 19.59 | 0..41 | Sodium-dependent dopamine transporter | SLC6A3 | Q01959 | 14.00 | |
| 19.59 | 0..41 | Activation peptide fragment 1 | F2 | P00734 | 14.00 | |
|
| ||||||
| Genipin 1-gentiobioside | 45.58 | 0.83 | Microtubule-associated protein tau | MAPT | P10636 | 71.00 |
| 45.58 | 0.83 | Hypoxia-inducible factor 1-alpha | HIF1A | Q16665 | 31.00 | |
| 45.58 | 0.83 | Endothelial PAS domain-containing protein 1 | EPAS1 | Q99814 | 31.00 | |
| 45.58 | 0.83 | Tyrosine-protein phosphatase nonreceptor type 2 | PTPN2 | P17706 | 20.00 | |
| 45.58 | 0.83 | Tyrosine-protein phosphatase nonreceptor type 1 | PTPN1 | P18031 | 20.00 | |
| 45.58 | 0.83 | Transient receptor potential cation channel subfamily V member 1 | TRPV1 | Q8NER1 | 14.00 | |
| 45.58 | 0.83 | Activation peptide fragment 1 | F2 | P00734 | 13.00 | |
| 45.58 | 0.83 | Transient receptor potential cation channel subfamily V member 4 | TRPV4 | Q9HBA0 | 13.00 | |
| 45.58 | 0.83 | Transient receptor potential cation channel subfamily V member 2 | TRPV2 | Q9Y5S1 | 13.00 | |
| 45.58 | 0.83 | Tyrosyl-DNA phosphodiesterase 1 | TDP1 | Q9NUW8 | 11.00 | |
| 45.58 | 0.83 | D (1A) dopamine receptor | DRD1 | P21728 | 10.00 | |
| 45.58 | 0.83 | D (1B) dopamine receptor | DRD5 | P21918 | 10.00 | |
| 45.58 | 0.83 | Motilin receptor | MLNR | O43193 | 10.00 | |
| 45.58 | 0.83 | Growth hormone secretagogue receptor type 1 | GHSR | Q92847 | 10.00 | |
| 45.58 | 0.83 | D (2) dopamine receptor | DRD2 | P14416 | 9.00 | |
|
| ||||||
| Gardoside | — | — | Microtubule-associated protein tau | MAPT | P10636 | 86.00 |
| — | — | Hypoxia-inducible factor 1-alpha | HIF1A | Q16665 | 22.00 | |
| — | — | Endothelial PAS domain-containing protein 1 | EPAS1 | Q99814 | 22.00 | |
| — | — | Glycine receptor subunit alpha-1 | GLRA1 | P23415 | 19.00 | |
| — | — | Glycine receptor subunit alpha-2 | GLRA2 | P23416 | 19.00 | |
| — | — | Glycine receptor subunit alpha-3 | GLRA3 | O75311 | 19.00 | |
| — | — | Glycine receptor subunit beta | GLRB | P48167 | 19.00 | |
| — | — | Glycine receptor subunit alpha-4 | GLRA4 | Q5JXX5 | 19.00 | |
| — | — | Corticosteroid 11-beta-dehydrogenase isozyme 1 | HSD11B1 | P28845 | 12.00 | |
| — | — | Hydroxysteroid 11-beta-dehydrogenase 1-like protein | HSD11B1L | Q7Z5J1 | 12.00 | |
| — | — | Tyrosyl-DNA phosphodiesterase 1 | TDP1 | Q9NUW8 | 12.00 | |
| — | — | Protein kinase C gamma type | PRKCG | P05129 | 10.00 | |
| — | — | Protein kinase C beta type | PRKCB | P05771 | 10.00 | |
| — | — | Protein kinase C alpha type | PRKCA | P17252 | 10.00 | |
| — | — | Protein kinase C theta type | PRKCQ | Q04759 | 10.00 | |
|
| ||||||
| Shanzhiside | 117.77 | 0.10 | Microtubule-associated protein tau | MAPT | P10636 | 89.00 |
| 117.77 | 0.10 | Hypoxia-inducible factor 1-alpha | HIF1A | Q16665 | 19.00 | |
| 117.77 | 0.10 | Endothelial PAS domain-containing protein 1 | EPAS1 | Q99814 | 19.00 | |
| 117.77 | 0.10 | Tyrosyl-DNA phosphodiesterase 1 | TDP1 | Q9NUW8 | 14.00 | |
| 117.77 | 0.10 | Protein kinase C alpha type | PRKCA | P17252 | 14.00 | |
| 117.77 | 0.10 | Protein kinase C delta-type regulatory subunit | PRKCD | Q05655 | 14.00 | |
| 117.77 | 0.10 | Protein kinase C gamma type | PRKCG | P05129 | 14.00 | |
| 117.77 | 0.10 | Protein kinase C beta type | PRKCB | P05771 | 14.00 | |
| 117.77 | 0.10 | Protein kinase C theta type | PRKCQ | Q04759 | 14.00 | |
| 117.77 | 0.10 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | HSD11B1 | P28845 | 14.00 | |
| 117.77 | 0.10 | Hydroxysteroid 11-beta-dehydrogenase 1-like protein | HSD11B1L | Q7Z5J1 | 14.00 | |
| 117.77 | 0.10 | Glycine receptor subunit alpha-1 | GLRA1 | P23415 | 10.00 | |
| 117.77 | 0.10 | Glycine receptor subunit alpha-2 | GLRA2 | P23416 | 10.00 | |
| 117.77 | 0.10 | Glycine receptor subunit alpha-3 | GLRA3 | O75311 | 10.00 | |
| 117.77 | 0.10 | Glycine receptor subunit beta | GLRB | P48167 | 10.00 | |