Table 5.

Classification and information on target components-related pathways, direct (top 20).

Classification	Pathway	P value	Annotated genes count
Signaling molecules and interaction	Neuroactive ligand-receptor interaction	4.25E − 24	15
Signal transduction	GPCR downstream signaling	1.17E − 15	15
	Signaling by GPCR	6.64E − 14	15
	Class A/1 (rhodopsin-like receptors)	9.8E − 14	10
	GPCR ligand-binding	2.95E − 12	10
	Peptide ligand-binding receptors	1.98E − 10	7
	G alpha (z) signaling events	5.01E − 10	5
	Dopamine receptors	5.3E − 09	3
	HIF-1 signaling pathway	2.24E − 08	5
Organismal systems	Inflammatory mediator regulation of TRP channels	1.38E − 14	8
	Dopaminergic synapse	1.47E − 11	7
Human diseases	Amphetamine addiction	3.01E − 09	5
	EGFR tyrosine kinase inhibitor resistance	6.47E − 09	5
	Morphine addiction	1.32E − 08	5
Cellular processes	Gap junction	1.12E − 08	5
Transport of small molecules	Ion channel transport	7.04E − 12	8
	Ligand-gated ion channel transport	1.95E − 11	5
	Transmembrane transport of small molecules	1.44E − 10	10
Hemostasis	Platelet activation, signaling, and aggregation	3.32E − 09	7
	Disinhibition of SNARE formation	5.3E − 09	3